Receptive ano-rectal intercourse is a major cause of HIV infection in men having sex with men and in heterosexuals.Current knowledge of the mechanisms of entry and dissemination during HIV rectal transmission is scarce and does Engine Lowering Kits not allow the development of preventive strategies.We investigated the early steps of rectal infectio
Hydro-Servo-Aero-Elastic Analysis of Floating Offshore Wind Turbines
A fully coupled hydro-servo-aero-elastic simulator for the analysis of Carvin skimmer parts floating offshore wind turbines (FOWTs) is presented.All physical aspects are addressed, and the corresponding equations are concurrently solved within the same computational framework, taking into account the wind and wave excitations, the aerodynamic respo
Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages
BackgroundMelanoma has the highest mortality rate among all the types of skin cancer.In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with Prostate Supplements the invasiveness of tumor cells and a poor prognosis.Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the inhibition of tumor progression.The